Effects of tonicities and solutes of solutions on the lethality and the survival time after intraduodenal administration of ephedrine hydrochloride in mice.
The effects of transmucosal fluid movement and glucose on intestinal drug absorption, which were revealed in previous in situ experiments, were studied in vivo using intraduodenal administration to mice. These effects were reflected on the indices of lethality and survival time after ephedrine hydrochloride administration. The effects of transmucosal fluid movement and glucose were observed realistically in the in vivo experiment. Calcium chloride appeared to have an effect similar to glucose on drug absorption from the small intestine.