Facile Synthesis of Completely Protected Enantiomerically Pure α,α-Disubstituted α-Amino Acids
- 1 July 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (07) , 665-666
- https://doi.org/10.1055/s-1996-5545
Abstract
α,α-Disubstituted α-amino acids are synthesized from readily available β-ketoesters by a three step procedure: Beckmann rearrangement, protection of the lactam followed by nucleophilic ring opening.Keywords
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