CHRONIC CUTANEOUS GRAFT VERSUS HOST DISEASE IN MAN

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 91  (3) , 545-+
Abstract
The clinicopathologic study of patients with chronic graft vs. host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute GVHD; in 8 it occurred after the resolution of acute GVHD; and in 5 it arose without preceding acute GVHD, i.e., de novo late onset. Two cutaneous types were distinguished. The generalized type affected 16 patients and ran a progressive course resulting in late complications of poikiloderma, diffuse dermal and s.c. fibrosis and contractures. Microscopically, it resembled generalized morphea and lupus erythematosus hypertrophicus et profundus. The local type affected 3 patients with a more variable picture of poikiloderma, dermal sclerosis and contractures. Microscopically, it resembled lupus erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD were proposed.

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