(-)Pentobarbital Opens Ion Channels of Long Duration in Cultured Mouse Spinal Neurons
- 25 July 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4455) , 507-509
- https://doi.org/10.1126/science.6248961
Abstract
Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.Keywords
This publication has 29 references indexed in Scilit:
- Pentobarbital: Stereospecific Actions of (+) and (-) Isomers Revealed on Cultured Mammalian NeuronsScience, 1980
- Phenobarbitone modulation of postsynaptic GABA receptor function on cultured mammalian neuronsProceedings of the Royal Society of London. B. Biological Sciences, 1979
- Inosine May Be an Endogenous Ligand for Benzodiazepine Receptors on Cultured Spinal NeuronsScience, 1979
- Pharmacological characterization of different types of GABA and glutamate receptors in vertebrates and invertebrates☆☆☆Progress in Neurobiology, 1979
- Interaction of barbiturates with dihydropicrotoxinin binding sites related to the GABA receptor-ionophore systemLife Sciences, 1978
- CONDUCTANCE FLUCTUATIONS AND IONIC PORES IN MEMBRANESAnnual Review of Biophysics and Bioengineering, 1977
- CALCIUM‐INDUCED RELEASE OF γ‐AMINOBUTYRIC ACID FROM SYNAPTOSOMES: EFFECTS OF TRANQUILIZER DRUGSJournal of Neurochemistry, 1977
- Channel noise in nerve membranes and lipid bilayersQuarterly Reviews of Biophysics, 1975
- Pentobarbital: Selective Depression of Excitatory Postsynaptic PotentialsScience, 1973
- Anaesthetic agents and the chemical sensitivity of cortical neuronesNeuropharmacology, 1970