Effects of Adrenergic and Cholinergic Drugs on Splenic Inflow and Outflow Before and During Adrenergic Blockade

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Abstract
Blood flows (electromagnetic flow-meters) and lateral pressures were recorded simultaneously from the splenic artery and vein during intra-arterial injections of adrenergic substances and methacholine. These injections were repeated after progressively increasing doses of the adrenergic blocking agent phenoxy-benzamine. Epinephrine and arterenol simultaneously reduced arterial inflow and increased venous outflow and splenic vein pressure, and reduced splenic volume. Isoproterenol and methacholine, and epinephrine and arterenol during partial adrenergic blockade, increased arterial inflow and venous outflow and pressure, and increased splenic volume. This is the only vascular bed so far studied in which any significant degree of reversal of arterenol arteriolar constriction has been noted.