Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?
- 4 September 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 528 (1-3) , 3-4
- https://doi.org/10.1016/s0014-5793(02)03248-9
Abstract
A gene family containing a longevity assurance gene (Lag1p) motif is described. Database searches revealed >40 members of this family of transmembrane proteins, two of which have recently been shown to regulate the synthesis of ceramide, a lipid second messenger involved in a variety of cellular processes. We speculate that other family members, some of which contain a Hox domain, may also be involved in the synthesis of specific ceramide pools, perhaps explaining the role of longevity assurance genes in regulating development.Keywords
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