Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones
- 1 July 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 27 (7) , 894-900
- https://doi.org/10.1021/jm00373a015
Abstract
A series of novel triazol-3-ones were synthesized, and their in vitro and in vivo antifungal properties are reported. Itraconazole, which displays a pronounced oral activity vaginal candidosis in rats and against microsporosis in guinea pigs, was selected for clinical evaluation.This publication has 0 references indexed in Scilit: