Carcinogenic Effect of N -Nitroso-2,6-dimethylmorpholine in Syrian Golden Hamsters

1 February 1978

journal article
research article
Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute

Vol. 60 (2) , 371-378
https://doi.org/10.1093/jnci/60.2.371

Abstract

N-Nitroso-2,6-dimethylmorpholine was intragastrically administered to Syrian golden hamsters at four different dose levels [74 mg/kg body wt=1/5 median lethal dose (LD50); 37 mg/kg body wt=1/10 LD50; 18 mg/kg body wt=1/20 LD50; and 9 mg/kg body wt=1/40 LD50). Up to a 71% rate of pancreatic tumors was induced. These tumors were adenomas or adenocarcinomas of ductal origin. In addition, neoplasms developed in different percentages in the nasal cavities, larynx, trachea, lungs, liver, gallbladder, kidneys, and forestomach. The number of tumors induced was not significantly dose-dependent.

Keywords

This publication has 1 reference indexed in Scilit:

Metabolism of the Pancreatic Carcinogens N -Nitroso-bis(2-oxopropyl)amine and N -Nitroso-bis(2-hydroxypropyl)amine in the Syrian Hamster 2
JNCI Journal of the National Cancer Institute, 1976