Asphyxia Relatively Inherent to Tranquilization
- 1 February 1965
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 12 (2) , 152-158
- https://doi.org/10.1001/archpsyc.1965.01720320040005
Abstract
IT WOULD BE superfluous to introduce additional examples of the documental rise in attempted and completed suicides28,52,54,68 and sudden unexplained deaths10,12,26,67,71 among the normal and schizophrenic population therapeutically exposed to tranquilization. The purpose of this paper is to introduce the mechanism and pathogenesis previously not documented, as far as I can ascertain, in case reports of sudden unexplained deaths of patients on tranquilization. Asphyxia, a term applied to a definite sequence of clinical symptoms, is a result of a physiopathological process implicated and influenced by ataraxics acting upon the central nervous system (CNS)3,4,16,37 resulting in gastroesophageal reflux,7,8,14,22,31 respiratory insufficiency and failure.23,34,46 The adverse behavioral affect on the CNS attributed to chlorpromazine,6,18,20,35 promazine,44,47,73 reserpine,15,74 and other tranquilizers17,19,63,64 emerged with a characteristic clinical pattern in both children and adults, exKeywords
This publication has 11 references indexed in Scilit:
- Changes in the electroencephalogram during chronic administration of tranquilizing drugsElectroencephalography and Clinical Neurophysiology, 1959
- Depressive Reactions in Hypertensive PatientsCirculation, 1959
- ESOPHAGEAL CATHETERIZATION STUDIES. I. THE MECHANISM OF SWALLOWING IN NORMAL SUBJECTS WITH PARTICULAR REFERENCE TO THE VESTIBULE (ESOPHAGO-GASTRIC SPHINCTER)*Journal of Clinical Investigation, 1959
- Esophageal MotilityPhysiological Reviews, 1958
- Resistance and Reflex Function of the Lower Esophageal SphincterJournal of Applied Physiology, 1958
- PHYSIOLOGICAL-STUDIES AFTER CONTINUOUS SERPASIL THERAPY OVER 18 MONTHS1956
- CHLORPROMAZINE IN THE TREATMENT OF NEUROPSYCHIATRIC DISORDERSJAMA, 1954
- A Comparison of the Effects of Acetyl-Beta-Methylcholine Chloride (Mecholyl) on Esophageal Intraluminal Pressure in Normal Persons and Patients with CardiospasmGastroenterology, 1954
- The Disturbance of Esophageal Motility in Cardiospasm: Studies on Autonomic Stimulation and Autonomic Blockade of the Human Esophagus, Including the CardiaGastroenterology, 1953
- A NEURAL BASIS OF THE ANESTHETIC STATEArchives of Neurology & Psychiatry, 1953