Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
- 31 December 2001
- journal article
- brief communcation
- Published by Wiley in Annals of Neurology
- Vol. 51 (1) , 133-136
- https://doi.org/10.1002/ana.10079
Abstract
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain‐derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (χ2 = 5.46) and confirmed an association with the S18Y polymorphism of the UCH‐L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.Keywords
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