Partial-Body X-Ray Exposure and the Development of Progressive Intercapillary Glomerulosclerosis in the BALB/ c Mouse

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Abstract
BALB/c mice were subjected to whole- or partial-body X-ray (250-kv) exposure at 58 to 93 days of age. After sacrifice 500 days later, their kidneys were graded for intercapillary glomerulo-sclerosis (IGS), a naturally occurring aging process, accelerated by irradiation. The results lead to the conclusion that it is the absorbed dose of radiation in each kidney itself that determines the acceleration in the development of IGS. The high X-ray dose (750 and 900 rads) possible under conditions of partial-body irradiation resulted in more severe glomerular lesions than previously observed and in the appearance of early renal arteriosclerosis in association with the most advanced degrees of IGS.