Effect of Leukotriene D4 on Tracheal Mucociliary Transport Velocity in Quails
Open Access
- 1 January 1996
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 70 (2) , 195-198
- https://doi.org/10.1254/jjp.70.195
Abstract
We investigated the effect of leukotriene D4 (LTD4) on tracheal mucociliary transport in quails. Topical application of LTD4 (0.2-2 ng) to tracheal mucosa dose-dependently increased mucociliary transport velocity (MCTV) in 5 or 10 min after application. Forty minutes after application of 2 ng of LTD4, MCTV was decreased to about 84% of that in the control group. Both the transient increase and the subsequent decrease induced by 2 ng of LTD4 were blocked by ONO-1078 (Pranlukast: 4-oxo-8-[4-(4-phenylbutoxy)-benzoylamino]-2-(tetrazol-5-yl)- 4H- 1-benzopyran) (0.03-3 mg/kg, i.m.), a specific leukotriene antagonist. These results suggest that LTD4 possesses a biphasic effect on tracheal mucociliary transport through leukotriene receptors.Keywords
This publication has 12 references indexed in Scilit:
- Cough-Diversity and the peripheral mechanisms of production.Folia Pharmacologica Japonica, 1995
- Polyphosphoinositide hydrolysis and protein kinase C activation in guinea pig tracheal smooth muscle cells in culture by leukotriene D4 involve a pertussis toxin sensitive G-proteinEuropean Journal of Pharmacology: Molecular Pharmacology, 1992
- In Vitro Antagonism of ONO-1078, a Newly Developed Anti-Asthma Agent, against Peptide Leukotrienes in Isolated Guinea Pig Tissues.The Japanese Journal of Pharmacology, 1992
- Platelet-activating factor impairs mucociliary transport and increases plasma leukotriene B4 in manEuropean Respiratory Journal, 1991
- Stimulation of airway ciliary motility by immunologically activated canine pulmonary macrophages: role of leukotrienesActa Physiologica Scandinavica, 1991
- Characterization of the guinea pig lung membrane leukotriene D4 receptor solubilized in an active form. Association and dissociation with an islet-activating protein-sensitive guanine nucleotide-binding protein.Journal of Biological Chemistry, 1990
- Influence of corticosterone on tracheal mucociliary transport in pigeons.The Japanese Journal of Pharmacology, 1990
- Ciliary responsiveness in allergic and nonallergic airwaysJournal of Applied Physiology, 1986
- Effects of leukotriene D4 on mucociliary and respiratory function in allergic and nonallergic sheepJournal of Applied Physiology, 1985
- Immunologic and Neuropharmacologic Stimulation of Mucous Glycoprotein Release from Human Airways In VitroJournal of Clinical Investigation, 1980