Lysosomes and lysosomal enzyme activity in the regenerating planarian; Evidence in support of dedifferentiation

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Abstract
The lysosomal enzyme acid phosphatase has been shown to increase in activity rapidly during the first 12 hours of cephalic regeneration in the planarian Dugesia dorotocephala. This increase was correlated with the cytological demonstration of lysosomes in dedifferentiating cells and the electron microscopical cytochemical localization of acid phosphatase in lysosomes. These findings are interpreted as being consistent with the dedifferentiation hypothesis for the origin of blastema cells.