DIAGNOSIS AND TREATMENT OF ADDISON'S DISEASE

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To the Editor: —The recent article by myself and my co-workers on the "Diagnosis and Treatment of Addison's Disease," which appeared inThe Journal, June 10, should have described in detail, and not merely by citation, the work of Dr. R. F. Loeb and his co-workers in New York, on the general influence of the suprarenal glands on sodium metabolism. The low concentration of sodium in the blood serum of patients during the crisis of Addison's disease was reported last year by Loeb inScience(76:420 [Nov. 4] 1932). Dr. Loeb subsequently observed a patient with Addison's disease who recovered rapidly from an acute crisis with sodium chloride therapy alone. The subsequent appearance of edema caused this patient to be given a salt-poor diet. She promptly showed symptoms of insufficiency, from which she was again relieved by the use of salt alone. A description of this case, together with

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