Three-Generation Pedigree of a Mobius Syndrome Variant With Chromosome Translocation

Abstract
• We report the clinical and cytogenetic data on seven members of a family, spanning three generations, who showed congenital facial diplegia and finger contractures. Each affected member showed an identical chromosome abnormality, reciprocal translocation between chromosome 1 and 13. The concurrence of the clinical and cytogenetic defect in this family suggests a direct and possibly etiologic relationship.