PREVENTION OF IMPLANTATION IN RATS BY I.C.I. 46,474: ROLE OF HISTAMINE

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Abstract
SUMMARY: Implantation was largely prevented in rats given a single dose of I.C.I. 46,474 on day 4 of pregnancy. Aminoguanidine bicarbonate given on days 2–5 inclusively prevented this effect in intact, but not in adrenalectomized rats. Neither histamine dihydrochloride nor dl-histidine prevented the effect of I.C.I. 46,474 on implantation. Histidine, but not histamine, prevented the action of aminoguanidine in intact pregnant rats given I.C.I. 46,474. The failure of aminoguanidine to reverse the effects of I.C.I. 46,474 in adrenalectomized rats indicates that I.C.I. 46,474 does not prevent implantation by virtue of its anti-histaminic activity.

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