Citric acid and bone metabolism

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Abstract
The "citrogenase" and aconitase activities of various rabbit bone regions are greater than that of isocitric dehydrogenase compared with kidney and liver. In extension of earlier observations increasing concns. of citrate inhibit the calcification of hypertrophic rat cartilage in vitro. Enzyme levels in bone indicate the greater metabolic activities of metaphysis and epiphysis over that of cortex. Amts. of citrate in bone regions are in inverse ratio to their metabolic activities. The higher "citrogenase" and lower isocitric dehydrogenase levels in bone regions may produce local increased concns. of citric acid which may then become co-precipitated during deposition of bone salt.