Facile, Fmoc-Compatible Solid-Phase Synthesis of Peptide C-Terminal Thioesters
- 8 July 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (16) , 2439-2442
- https://doi.org/10.1021/ol0060836
Abstract
A short route to peptide C-terminal thioesters was developed that does not require the use of special linkers or resins and is compatible with standard Fmoc chemistry. Following conventional solid-phase peptide synthesis, an excess of Me2AlCl and EtSH in dichloromethane cleaves peptides from Wang or Pam resins to give the corresponding thioesters directly in good yield and purity.Keywords
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