Effect of anti-inflammatory drugs on partitioning characteristics of propranolol and oxprenolol
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (1) , 51-52
- https://doi.org/10.1111/j.2042-7158.1984.tb02988.x
Abstract
The influence of a range of nine anti-inflammatory drugs on the octan-1-ol aqueous phosphate buffer pH 7·4 apparent partition coefficients of propranolol and oxprenolol has been examined. All produced a change in the apparent partition coefficient which can be explained in terms of partitioning of hydrophobic ion-pairs formed between the ionic anti-inflammatory compound and the protonated cationic drug.Keywords
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