Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus
Top Cited Papers
Open Access
- 30 May 2002
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 346 (22) , 1685-1691
- https://doi.org/10.1056/nejmoa012350
Abstract
It is unknown whether insulin therapy can delay or prevent diabetes in nondiabetic relatives of patients with diabetes.Keywords
This publication has 29 references indexed in Scilit:
- Islet Cell Antibody-Positive Relatives with Human Leukocyte Antigen DQA10102, DQB10602: Identification by the Diabetes Prevention Trial-Type 1Journal of Clinical Endocrinology & Metabolism, 2000
- Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice.Journal of Clinical Investigation, 1997
- Immunological and metabolic effects of prophylactic insulin therapy in the NOD-scid/scid adoptive transfer model of IDDMDiabetes, 1996
- HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDMDiabetes, 1995
- Prophylactic insulin treatment in relatives at high risk for type 1 diabetesDiabetes/Metabolism Research and Reviews, 1993
- Glucose regulation of the autoantigen GAD65 in human pancreatic isletsJournal of Clinical Endocrinology & Metabolism, 1992
- Prevention of adoptive transfer in BB rats by prophylactic insulin treatmentDiabetes, 1992
- Specific Intellectual Deficits in Children with Early Onset Diabetes MellitusChild Development, 1988
- Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitusDiabetes, 1987
- Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitusDiabetes, 1980