Effect of Thiazine, Oxazine and Phenazine Dyes on Normal and Heparinized Rabbit Plasma.

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Abstract
A study was made of the effect of 7 dyes of the phenazine, oxazine and thia-zine series on the invitro coagulation times of normal and heparinized rabbit plasma. Toluidine Blue, Azure A, Neutral Red effectively counteract the anticoagulant action of heparin but the amount of each dye required for this antiheparin effect is critical. At concns. below the critical level the dyes had little or no effect on the coagulation system studied. At concns. above the critical level all the dyes produced a progressively increased incoagulability of the system. This anticoagulant effect of the dyes is related to concn. and the action is on some substance other than heparin.
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