Von Recklinghausen's neurofibromatosis is generally thought of in terms of its skin manifestation. Indeed, it is defined as “a condition … marked superficially by the formation of multiple pedunculated soft tumors (neurofibromas) distributed over the entire body and associated with areas of pigmentation” (1). Were these the sole manifestations, the diagnostic roentgenologist need not be concerned with this disease, which is certainly not a rare one. The skin changes, however, are only the most common sign; there are numerous other clinical manifestations. Similarly, there are many and varied roentgenologic findings involving many of the organ systems. Awareness of the roentgenologic appearances would permit easy recognition of many forms which neurofibromatosis may take. From experience encountered in a general hospital, a number of cases are being reported to show the variety of roentgenologic findings and clinical manifestations associated with neurofibromatosis. These cases are chosen because the roentgenograms lend themselves to satisfactory reproduction or because they are of unusual clinical interest. No attempt has been made to present a complete review of multiple neurofibromatosis as seen in this hospital. It is hoped that the material will be of sufficient interest to alert the reader to the possibility of encountering similar examples. Case Reports Case I: B. C., a 38-year-old Negro female, obviously a mental defective, was admitted to the hospital because of a painful swelling over the left forearm. Multiple soft subcutaneous nodules of varying size, up to 4 cm. in diameter, were said to have been present since birth. There was moderate scoliosis of the upper dorsal spine. Café au lait spots were scattered over the trunk and extremities. No abnormal neurologic sign or symptom was present. An older sister had had similar tumors removed some years earlier at another hospital. One of the nodules was removed from the left forearm and proved to be a typical neurofibroma. Roentgenograms revealed destruction of the pedic1esof C-5, 6, and 7 and of the vertebral articulating portion of the left first rib (Fig. 1). There was marked kyphoscoliosis secondary to the destructive process. In the medial portion of the left ilium there was extensive bone erosion (Fig. 2). It is of interest that the largest subcutaneous nodules overlay this area. These destructive changes were undoubtedly due to neurofibromatosis. Scoliosis of the dorsal spine was readily apparent, but no bone defect was evident to account for this. A complete skeletal survey revealed no other abnormality. Case II3: R. G., a 5-year-old white girl, was seen because of obvious disparity in length of the lower extremities. The left leg was 1 5/8 inches longer than the right and was 2 inches greater in circumference at the calf.