Hypercalcemia in Reticulum Cell Sarcoma Without Hyperparathyroidism or Skeletal Metastases

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Abstract
A patient with reticulum cell sarcoma and hypercalcemia had a remission of the hypercalcemia after localized radiation therapy. The tumor and hypercalcemia recurred 2 years later. Examination of blood and tumor extract from the patient by a sensitive radioimmunoassay for parathyroid hormone failed to detect the hormone. Tumor extract raised serum calcium when injected into parathyroidectomized mice and caused release of 45Ca from mouse calvaria in vitro. At autopsy the patient had four normal parathyroid glands and no skeletal metastases. The humoral agent responsible for the hypercalcemia in this patient remains to be elucidated.

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