THE PRESENCE IN BLOOD OF A PRINCIPLE WHICH ELICITS A SUSTAINED PRESSOR RESPONSE IN NEPHRECTOMIZED ANIMALS

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Abstract
A pressor principle was found in the terminal blood of cats which have died as the result of certain undiagnosed "natural causes," DDT poisoning, and prolonged hypotension resulting from the withdrawal of blood. The pressor principle was not demonstrated in the blood plasma of bilaterally nephrectomized cats which died of DDT poisoning, prolonged hypotension or from uremia. The pressor principle was not found in the blood plasma obtained from normal living cats or normal cats which had been killed suddenly by various means. It caused a sustained elevation of blood pressure in cats which were unanesthetized, anesthetized or pithed, and had been bilaterally nephrectomized 2 days before. The injn. of the same amt. of plasma containing the pressor principle into non-nephrectomized cats did not cause a sustained elevation of blood pressure. It is concluded that a moderately prolonged period of hypotension (with diminished blood flow and/or blood pressure within the kidneys) is necessary for the production of the pressor principle. The pressor principle appears to be distinct from renin, an-giotonin, pepsitensin, hydroxytyramine, or tyramine because of the difference in the contour of the pressor response, the duration of the pressor response, and the difference in the conditions under which the response is observed.

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