Combined inhibition of neutral endopeptidase and angiotensin-converting enzyme by sampatrilat in essential hypertension*
- 16 October 1998
- journal article
- clinical trial
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 64 (4) , 439-449
- https://doi.org/10.1016/s0009-9236(98)90075-3
Abstract
The antihypertensive response to angiotensin‐converting enzyme (ACE) inhibitors may be attenuated by a compensatory decrease in atrial natriuretic factor production. If so, inhibition of atrial natriuretic factor breakdown by neutral endopeptidase (NEP) may enhance the antihypertensive effects of ACE inhibition. We compared effects of the combined ACE‐NEP inhibitor sampatrilat, lisinopril, and placebo on blood pressure, plasma ACE, and renin activity and urinary cyclic guanosine monophosphate (cGMP) of patients with hypertension.Keywords
This publication has 16 references indexed in Scilit:
- Effect of dose adjustment on enalapril‐induced cough and the response to inhaled capsaicin.British Journal of Clinical Pharmacology, 1995
- Candoxatril, a neutral endopeptidase inhibitorJournal Of Hypertension, 1992
- ATRIAL AND BRAIN NATRIURETIC PEPTIDES: SECRETION DURING EXERCISE IN PATIENTS WITH ESSENTIAL HYPERTENSION AND MODULATION BY ACUTE ANGIOTENSIN‐CONVERTING ENZYME INHIBITIONClinical and Experimental Pharmacology and Physiology, 1992
- Dietary sodium and inhibition of neutral endopeptidase 24.11 in essential hypertension.Hypertension, 1991
- Blunting of atrial natriuretic factor response to volume expansion by benazepril in hypertensive patientsJournal Of Hypertension, 1989
- Direct effect of α-human atrial natriuretic peptide on human vasculature in vivo and in vitroClinical Science, 1988
- Antihypertensive and hypotensive effects of atrial natriuretic factor in men.Hypertension, 1987
- Atrial natriuretic peptide: Evidence of action as a natriuretic hormone at physiological plasma concentrations in manClinical Science, 1987
- RENAL, HAEMODYNAMIC, AND HORMONAL EFFECTS OF HUMAN ALPHA ATRIAL NATRIURETIC PEPTIDE IN HEALTHY VOLUNTEERSThe Lancet, 1985
- Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.Hypertension, 1984