Subcellular Localization of Bioactive Cholecystokinin‐Like Peptides in the Rat Cerebral Cortex
- 1 March 1983
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 41 (3) , 890-892
- https://doi.org/10.1111/j.1471-4159.1983.tb04824.x
Abstract
The subcellular distribution of cholecystokinin (CCK), especially its exact localization within the synaptosome, was studied in the rat cerebral cortex. Highest CCK-like bioactivity was measured in the synaptic membrane fractions, paralleling the distribution of (Na+ + K+)-dependent ATPase. In the synaptic vesicles, which were characterized by high acetylcholine content and by the absence of (Na+ + K+)-ATPase, only minimal quantities of CCK were detected.Keywords
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