Distribution of Carbonic Anhydrase in Alligator. Effect of Acetazolamide on Blood and Aqueous Humor CO2

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Abstract
Carbonic anhydrase was found in the caiman (C. laitrostris) kidney which explains the acidification of the urine following carbonic anhydrase inhibition (Coulson, R. A. and T. Hernandez, Am. J. Physiol., 188, 121, 1957). The enzyme was also found in the erythrocytes, gastric mucosa, pancreas and hindbrain of the caiman and in the choroid plexus and ciliary processes of the alligator (A. mississippiensis). However, in contrast to the mammal and chicken no activity was found in the lens. Acetazolamide, intracardially, caused in the alligator a long-lasting rise of plasma total CO2, presumably due to inhibition of both blood and kidney enzyme. No certain change of the CO2 content of the anterior aqueous humor was observed.

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