Modelling the relative contribution of fasting and post-prandial plasma glucose to HbA1cin healthy and type 2 diabetic subjects

Abstract
Glycated haemoglobin (HbA1c) is regarded as the gold standard of glucose homeostasis assessment in diabetes. There has been much discussion in recent medical literature of experimental results concerning the relative contribution of fasting and post-prandial glucose levels to the value of HbA1c. A mathematical model of haemoglobin glycation is derived and investigated to address this issue.