A modified synthesis of 1 α-hydroxyvitamin D3
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1695-1697
- https://doi.org/10.1039/p19790001695
Abstract
Base-catalysed deconjugation of cholesta-1,4,6-trien-3-one to cholesta-1,5,7-trien-3-one is a key step in a reported route to 1α-hydroxyvitamin D3. A procedure for greatly improving the yield of the product, which allows its isolation via direct crystallisation, is reported. This procedure, used in conjunction with a recently described method for α-epoxidation of protected Δ1-3β-ols, has been employed in a relatively efficient synthesis of 1α-hydroxyvitamin D3.This publication has 0 references indexed in Scilit: