Dual dynamic contrast‐enhanced MR imaging

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Abstract
A method was devised for obtaining dynamic contrast‐enhanced T1‐weighted and relaxation rate (ΔR2*) images simultaneously to evaluate regional hemodyn‐amics of the brain tumors. On a 1.5‐T MR system, dual dynamic contrast‐enhanced images were obtained using a gradient echo (dual echo fast field echo) pulse sequence with the keyhole technique to improve temporal and spatial resolution during a rapid bolus injection of gadopentetate dimeglumine. The dynamic T1 contrast images were obtained from the first echo; moreover.∫ ΔR2*dt values were calculated from the first and the second echo images. The dynamic T1 contrast images provided information about characteristic enhancement pattern (vascularization and disruption of bloodbrain barrier), and the f ΔR2*dt values provided a map of regional blood pool in tumor site, peritumoral edema, and other surrounding regions of the brain. The ability to obtain dynamic contrast‐enhanced T1 contrast and ΔR2* imaging at the same time allows optimization of the advantages of each and thereby more information about the microvascular circulation of the brain lesions.