Correlation between In Vitro Susceptibility Determined by E Test and Response to Therapy with Amphotericin B: Results from a Multicenter Prospective Study of Candidemia
- 1 May 1999
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 43 (5) , 1289-1290
- https://doi.org/10.1128/aac.43.5.1289
Abstract
Ninety-nine Candida bloodstream isolates underwent testing for susceptibility to amphotericin B by the E test, and the results were correlated with patients’ responses to amphotericin B. The MICs for isolates that were associated with therapeutic failure were significantly higher than the MICs for those associated with therapeutic success. A MIC of ≥0.38 μg/ml identified isolates likely to be associated with therapeutic failure.Keywords
This publication has 11 references indexed in Scilit:
- Do In Vitro Susceptibility Data Predict the Microbiologic Response to Amphotericin B? Results of a Prospective Study of Patients withCandidaFungemiaThe Journal of Infectious Diseases, 1998
- Development of Interpretive Breakpoints for Antifungal Susceptibility Testing: Conceptual Framework and Analysis of In Vitro-In Vivo Correlation Data for Fluconazole, Itraconazole, and Candida InfectionsClinical Infectious Diseases, 1997
- The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistanceThe American Journal of Medicine, 1996
- Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: enhanced ability to detect amphotericin B-resistant Candida isolatesAntimicrobial Agents and Chemotherapy, 1995
- Detection of amphotericin B-resistant Candida isolates in a broth-based systemAntimicrobial Agents and Chemotherapy, 1995
- Development of resistance in candida isolates from patients receiving prolonged antifungal therapyAntimicrobial Agents and Chemotherapy, 1991
- Amphotericin B-resistant yeast infection in severely immunocompromised patientsThe American Journal of Medicine, 1988
- Fatal Disseminated Candidiasis Due to Amphotericin-B-Resistant Candida guilliermondiiAnnals of Internal Medicine, 1985
- Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a HumanAntimicrobial Agents and Chemotherapy, 1979
- Non-emergence of polyene-resistant yeasts: an hypothesis.1974