THE EFFECT OF LOW DOSES OF PREDNISOLONE COMPARED WITH PLACEBO ON FUNCTION AND ON THE HYPOTHALAMIC PITUITARY ADRENAL AXIS IN PATIENTS WITH RHEUMATOID ARTHRITIS

1 February 1976

journal article
clinical trial
Published by Oxford University Press (OUP) in Rheumatology

Vol. 15 (1) , 17-23
https://doi.org/10.1093/rheumatology/15.1.17

Abstract

A double-blind trial of prednisolone in patients with rheumatoid arthritis using doses of zero, 3 mg and 5 mg is reported. Patients on a dose of 3 mg derived little sustained benefit but subjects on the higher dose showed some improvement which did not last more than two years. Mild suppression of the hypothalamo-pituitary-adrenal axis occurred in both steroid-treated groups.

Keywords

ARTHRITIS
PREDNISOLONE
FUNCTION
RHEUMATOID
PITUITARY ADRENAL AXIS

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