CONGENITAL HYDROCEPHALUS WITH DEFECTIVE DEVELOPMENT OF THE CEREBELLAR VERMIS (DANDY-WALKER SYNDROME): Clinical and Anatomical Findings in Two Cases with Particular Reference to the So-called Atresia of the Foramina of Magendie and Luschka

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Abstract
Atresia of the foramina of Magendie and Luschka is not the primary factor in the development of congenital hydrocephalus with defective development of the cerebellar vermis and related clinical symptoms (Dandy-Walker Syndrome). The anatomical findings in the cases of 2 girls, ages 4 and 7 3/4 years, showed that the cerebellar vermis was underdeveloped posteriorly and the 4th ventricle had a greatly enlarged roof consisting of ependyma and connective tissue. In 1 case the foramina of Luschka were patent. These cases compared with studies of a strain of mice with similar malformations show that anomalies associated with this syndrome begin before the development of the foramina of Luschka and Magendie.