Histological Changes in Rat Bronchus-Associated Lymphoid Tissue after Administration of Five Different Antigens

1 January 1985

journal article
Published by S. Karger AG in Respiration

Vol. 48 (1) , 29-36
https://doi.org/10.1159/000194795

Abstract

Histological changes in bronchus-associated lymphoid tissue (BALT) following single intratracheal administration of five different antigens were studied in the rat. After administration of T-dependent antigens (i.e., horseradish peroxidase, bovine serum albumin, and Bacillus Calmette Guérin) only minor changes in BALT in the rat occurred. Intratracheal administration of a T-independent antigen (lipopolysaccharide) and a partly T-independent antigen (paratyphoid vaccine) resulted after 1 week in an increase in cytoplasmic IgM-containing (clgM) blast cells and plasma cells; these appeared to enter via the high endothelial venules (HEV). After 6 weeks, germinal centers were seen.

Keywords

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