A hsp70-related gene is constitutively highly expressed in testis of rat and mouse
- 1 March 1987
- journal article
- conference paper
- Published by Springer Nature in Molecular Biology Reports
- Vol. 12 (1) , 27-34
- https://doi.org/10.1007/bf00580647
Abstract
The expression pattern of major heat shock related genes (hsp70 gene family) in various organs of mouse and rat was investigated using Northern blot analysis. Heat shock gene related transcripts were detected in total RNA by hybridization with cloned mouse hsp70 gene sequences. Cells of various organs of intact mouse and rat constitutively synthesize a 2.2 kb and a 2.5 kb RNA. Exceptionally high levels of the 2.5 kb RNA, 50–250 fold higher than in other tissues are found in testis of both rodents. The 2.5 kb RNA hybridizes strongly to an extended region of mouse hsp70 gene; it also hybridizes poorly to the Drosophila hsp70 gene. The data suggest that the 2.5 kb RNA is transcribed from a hsp70-related gene in mouse and rat.This publication has 35 references indexed in Scilit:
- Levels of c-myc oncogene mRNA are invariant throughout the cell cycleNature, 1985
- The heat shock genes: A family of highly conserved genes with a superbly complex expression patternBioEssays, 1984
- Regulation of heat shock protein 70 gene expression by c-mycNature, 1984
- Accumulation of a heat shock-like protein during differentiation of human erythroid cell line K562Nature, 1984
- The major heat-shock protein (hsp70) gene family: related sequences in mouse, Drosophila, and yeastCanadian Journal of Biochemistry and Cell Biology, 1983
- Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene productCell, 1982
- Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regionsCell, 1980
- Studies of cloned sequences from four drosophila heat shock lociCell, 1979
- The induction of gene activity in drosophila by heat shockCell, 1979
- A membrane-filter technique for the detection of complementary DNABiochemical and Biophysical Research Communications, 1966