Effects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics

1 July 1997

journal article
research article
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 16 (7-9) , 1673-1676
https://doi.org/10.1080/07328319708006253

Abstract

Several acute toxicities in monkeys have been associated with administration of phosphorothioate oligonucleotides including effects on coagulation and complement cascades. These effects are transient in nature and the severity is closely associated with peak plasma concentrations of the oligonucleotide. Similar properties have been observed for several oligonucleotides with different base sequences.

Keywords

This publication has 2 references indexed in Scilit:

Progress in Antisense Oligonucleotide Therapeutics
Annual Review of Pharmacology and Toxicology, 1996
Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey
Antisense Research and Development, 1994