I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines
Open Access
- 2 October 2003
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 17 (15) , 2263-2265
- https://doi.org/10.1096/fj.02-1057fje
Abstract
The cardiac potassium channel encoded by the human ether-à-go-go related gene (HERG) is blocked by a diverse array of common therapeutic compounds. Even transient exposure to such agents may provoke ...Keywords
Funding Information
- American Heart Association
This publication has 39 references indexed in Scilit:
- A common polymorphism associated with antibiotic-induced cardiac arrhythmiaProceedings of the National Academy of Sciences, 2000
- MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac ArrhythmiaPublished by Elsevier ,1999
- KCR1, a Membrane Protein That Facilitates Functional Expression of Non-inactivating K+ Currents Associates with Rat EAG Voltage-dependent K+ChannelsPublished by Elsevier ,1998
- Taking the “Idio” out of “Idiosyncratic”: Predicting Torsades de PointesPacing and Clinical Electrophysiology, 1998
- Mutations in the hminK gene cause long QT syndrome and suppress lKs functionNature Genetics, 1997
- Molecular Genetic Insights into Cardiovascular DiseaseScience, 1996
- Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmiasNature Genetics, 1996
- A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channelCell, 1995
- A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndromeCell, 1995
- A family of potassium channel genes related to eag in Drosophila and mammals.Proceedings of the National Academy of Sciences, 1994