Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5'- Protecting Group Bearing an Imidazole Residue
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 17 (1) , 351-364
- https://doi.org/10.1080/07328319808005183
Abstract
Diastereoselective formation of internucleotidic phosphorothioate triester bonds was achieved by use of 3-(imidazol-1-ylmethyl)-4′,4″-dimethoxytrityl (IDTr) as a 5′-hydroxyl protecting group in the phosphotriester approach. After removal of all the protecting groups, stereochemistry of the major product was determined as the Spconfiguration by enzymatic digestion.Keywords
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