Effect of Intravenous Infusion of Glucose on Gastric Secretory Responses to Feeding in Pavlov‐ and Heidenhain‐pouch Dogs

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Abstract
Glucose solution was infused intravenously (30%, 80–100 ml, 30 min) in conscious dogs with Pavlov‐ or Heidenhain‐pouches during secretion elicited by different procedures. In Pavlov‐pouch dogs a pronounced inhibition of the secretory response was observed during sham‐feeding or teasing with food; the response to feeding was also temporarily depressed, at least during the first two hours after feeding. In Heidenhain‐dogs the response to feeding compared with the Pavlov‐dogs was not significantly affected except during special conditions. It is suggested that the induced hyperglycemia mainly depresses the nervous phase of secretion, possibly both at the central and the peripheral level.