The integration of molecular genetics into cancer management
- 15 September 1992
- Vol. 70 (S4) , 1653-1658
- https://doi.org/10.1002/1097-0142(19920915)70:4+<1653::aid-cncr2820701603>3.0.co;2-1
Abstract
Many of the phenotypes of cancer cells and tumors can now be traced to specific mutations in the genomes of these cells. These mutations may activate oncogenes, providing mitogenic stimulus to these cells. Alternatively, they may inactivate tumor-suppressor genes, relieving growth-inhibiting constraints placed on these cells. These genetic lesions together provide many of the explanations for the deregulated growth of tumor cells.Keywords
This publication has 27 references indexed in Scilit:
- Mechanisms of p53 loss in human sarcomas.Proceedings of the National Academy of Sciences, 1990
- Tumor Suppressor Genes: The Puzzle and the PromiseScience, 1989
- Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian CancerScience, 1989
- The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene ProductScience, 1989
- Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene productNature, 1988
- SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility geneCell, 1988
- The Approaching Era of the Tumor Suppressor GenesScience, 1987
- Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cellsCell, 1987
- CELLULAR ONCOGENES AND RETROVIRUSESAnnual Review of Biochemistry, 1983
- Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsCell, 1982