Chromosomes of human endometrial cells
- 1 January 1970
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 9 (3) , 199-211
- https://doi.org/10.1159/000130090
Abstract
Chromosome studies of cultured cells derived from endometrial biopsies obtained from 56 healthy women undergoing normal menstrual cycles and two women in the menopause and from five decidual biopsies revealed that 85.0% of the total cells counted (3602) had the modal chromosome number, 11.9% were hypomodal and 3.1% were hypermodal. These results varied only very slightly from counts of cells of chromosomally normal embryos cultured under identical conditions. This distribution of the counts and the fact that karyotype analyses of 608 cells revealed random losses (or, very rarely, gains) of chromosomes in cells from 61 of the 63 cases studied strongly suggest that most of the aneuploid cells result from technical artifacts. Therefore, it is concluded that, in contrast to several older reports but in agreement with some recent reports, the vast majority of endometrial and decidual cells possess a full chromosome complement, even after several cell divisions in vitro.Keywords
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