The Effect of SST, Glucagon, Calcitonin and PGEi on Exocrine Pancreatic Secretion in the Unrestrained Dog in Long-Term Experiments

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Abstract
Using a new model of a reversible pancreatic fistula which allows the long-term-investigation under nearly physiological conditions on the unrestrained dog, we tested the effect of somatostatin (50 µg), calcitonin (4 µg), glucagon (1 mg), and prostaglan-dine E1 (150 µg) on the exocrine pancreatic function in 45 experiments over a period of 13 h: SST inhibits the basal as well as the secretin or CCK-stimulated secretion: calcitonin shows inhibition of the stimulated secretion only; glucagon blocks the secretin-stimulated pancreatic function; and PGE1 reduces the bicarbonate concentration and trypsin output in secretin stimulation, but in one of the two series it stimulates the basal secretion.