SUPPRESSIVE EFFECT OF INTERFERON ON ERYTHROID CELL-PROLIFERATION

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 7  (3) , 145-150
Abstract
The effect of interferon on mouse and human in vitro erythropoiesis was investigated using the mouse marrow CFU-E [erythroid colony forming units] and the human blood BFU-E [erythropoietic burst-forming units] systems, respectively. Homologous interferons had a marked inhibitory effect on mouse CFU-E and human BFU-E proliferation. This inhibitory effect was dose-related and independent of the erythropoietin concentration used. The effective concentration of human interferon was within the range observed in humans following viral infections. Interferon may play a role in the mechanism of the acute erythroblastopenic crisis observed at times in patients with chronic anemia following viral infections.