Six-Step Synthesis of (S)-Brevicolline from (S)-Nicotine
- 13 July 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (16) , 3549-3552
- https://doi.org/10.1021/ol061334h
Abstract
[reaction: see text] A six-step synthesis of (S)-brevicolline from (S)-nicotine is reported. Regioselective trisubstitution of the pyridine ring of nicotine, followed by successive Suzuki cross-coupling and Buchwald amination reactions, afforded the enantiopure beta-carboline alkaloid, brevicolline.Keywords
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