The P Domain of the P0 Protein ofPlasmodium falciparumProtects against Challenge with Malaria Parasites
Open Access
- 1 September 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (9) , 5515-5521
- https://doi.org/10.1128/iai.72.9.5515-5521.2004
Abstract
Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.Keywords
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