Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
Open Access
- 1 June 2002
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 282 (6) , C1191-C1198
- https://doi.org/10.1152/ajpcell.00475.2001
Abstract
Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+signaling. The NAADP receptor and its associated Ca2+pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+channel is still an unanswered question.Keywords
This publication has 48 references indexed in Scilit:
- Structural and Functional Characterization of Human NAD KinaseBiochemical and Biophysical Research Communications, 2001
- Physiological Functions of Cyclic ADP-Ribose and NAADP as Calcium MessengersAnnual Review of Pharmacology and Toxicology, 2001
- Nicotinic acid‒adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cellsBiochemical Journal, 2001
- Widespread Distribution of Binding Sites for the Novel Ca2+-mobilizing Messenger, Nicotinic Acid Adenine Dinucleotide Phosphate, in the BrainJournal of Biological Chemistry, 2000
- Characterization of NAADP+ Binding in Sea Urchin EggsBiochemical and Biophysical Research Communications, 2000
- Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca2+ ReleasePublished by Elsevier ,2000
- Pharmacological properties of the Ca2+‐release mechanism sensitive to NAADP in the sea urchin eggBritish Journal of Pharmacology, 1997
- Activation and Inactivation of Ca Release by NAADPPublished by Elsevier ,1996
- Accumulation of cyclic ADP‐ribose measured by a specific radioimmunoassay in differentiated human leukemic HL‐60 cells with all‐trans‐retinoic acidFEBS Letters, 1995
- Enzymatic-Synthesis and Degradation of Nicotinate Adenine Dinucleotide Phosphate (NAADP), a Ca2+-Releasing Agonist, in Rat TissuesBiochemical and Biophysical Research Communications, 1995