A Role for a Sterol and a Sterol Precursor in the Bacterium Rhodopseudomonas palustris

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Abstract
SUMMARY: The multiplication of the purple photosynthetic bacterium Rhodopseudomonas palustris is inhibited by the hypocholesteraemic agents benzmalecene and triparanol. This inhibition is annulled by oleic acid, ergosterol, squalene, farnesol and lanosterol, in that order, but not by mevalonic acid, geranyl acetate, palmitic or stearic acids. Only oleic acid annuls the inhibition in higher concentrations of the inhibitors. Ergosterol and squalene, while not effective against higher concentrations of inhibitor, spared the annulment by oleic acid. An unknown interaction between oleic acid and sterols or their precursors is suggested.

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