THERAPEUTIC EFFECT OF DOPAMINE INFUSION ON HUMAN-MALIGNANT MELANOMA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (8) , 1657-1659
Abstract
Dopamine is a novel antitumor agent that has shown activity against [mouse] B16 melanoma. Four patients with advanced malignant melanoma were infused with dopamine at 20 .mu.g/kg per min for 48-120 h. Tumor and bone marrow samples were obtained before and after treatment for comparison. Each of the patients tested showed significant reduction in the labling index of tumor cells following treatment. Dopamine is apparently capable of attaining cytotoxic levels necessary to induce a biochemical inhibition of human malignant melanoma.