Suppression of piperidine-mediated side product formation for Asp(OBut)-containing peptides by the use of N-(2-hydroxy-4-methoxybenzyl)(Hmb) backbone amide protection
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 2343-2344
- https://doi.org/10.1039/c39940002343
Abstract
Piperidine-mediated aspartimide and subsequent piperidide formation, during Fmoc-based synthesis of sensitive aspartyl (β-tert-butyl ester, OBut)-containing peptides, is completely suppressed by the use of Hmb protection of the aspartyl amide bond.Keywords
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