Tungstate Antagonism of Molybdate in Aspergillus niger.

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Abstract
When nitrate was the sole N source for A. niger, tungstate in a molar ratio of 20/1 with Mo readily produced growth inhibition, and a ratio of 400/1 prevented growth almost completely. The inhibition was entirely reversed by adding sufficient molybdate to give a W/Mo ratio of 1. The tungstate molybdate growth interaction yielded a competitive inhibition type of Lineweaver-Burk plot. The fungus displayed no requirement for Mo when grown on an otherwise adequate medium containing ammonium as the source of N.